• br Material and methods br Results The search for

  2022-08-12

  

  Material and methods Results The search for proteins selectively expressed in pancreatic islet EDTA in the Human Protein Atlas (HPA) yielded 27 hits, including well-known islet cell markers such as insulin, glucagon and pancreatic polypeptide (Table 1). The search algorithm excluded islet cel

• Through the analysis of various

  2022-08-12

  

  Through the analysis of various synthetic GPR40 agonists as reported in literature, we found that a number of these compounds contained a phenylpropanoic 3,4-DAA motif which was inspired from naturally occurring medium to long chain fatty acids. For instance, in the early period of discovering TAK-8

• During the tests in vitro SHP showed the beneficial

  2022-08-12

  

  During the tests in vitro, SHP289-04 showed the beneficial effect on both two important aspects. In human liver carcinoma cell line HepG2, it was found to improve glucose consumption significantly. Otherwise, in pancreas cell line NIT1, it could only promote insulin secretion significantly at high g

• br GSMs Secretase cleavage of APP generates

  2022-08-12

  

  GSMs γ-Secretase cleavage of APP generates a number of Aβ peptides [32], [137]. In most cells Aβ1–37, 38, 39, and 42 are produced at low levels (typically each represents 5–20% of total Aβ detected) and the major species generated is Aβ1–40 (typically over 50% of total Aβ). Other Aβ peptides can

• br Introduction Alzheimer s disease AD

  2022-08-12

  

  Introduction Alzheimer's disease (AD) affects ca. 46 million people worldwide [1] and it is expected that the number will double or triple by 2030 or 2050, respectively, while no significant progress has been made in research for early diagnosis and new efficient therapies. Currently available me

• Development of few more dihydroxy pyrimidine and N methylpyr

  2022-08-11

  

  Development of few more dihydroxy-pyrimidine and N-methylpyrimidone analogues as HIV-integrase inhibitors was attempted involving substitution of variety of five- and six-membered rings via the introduction of a simple methyl substituent in the α-position of the C-2 side chains in order to improve p

• br Methods br Results br

  2022-08-11

  

  Methods Results Discussion In the general population BNP has been established as a marker for calculate dilution failure diagnosis. Moreover, there is growing evidence that elevated levels of natriuretic-peptides may improve CV risk prediction in the general population above traditional ri

• br Conclusion The hub gene KIBRA and the

  2022-08-11

  

  Conclusion The hub gene KIBRA and the Hippo signaling pathway were downregulated and miR-21 was upregulated in LAD. MiR-21 promoted the viability and mobility of LAD cells, reduced apoptosis and suppressed the Hippo signaling pathway in LAD through targeting KIBRA. Funding The study was appro

• The Hardy Weinberg equilibrium was

  2022-08-11

  

  The Hardy-Weinberg equilibrium was verified in all groups using the chi-square test. Using WINPEPI 11.65, the number of carriers and non-carriers of the Δ32 allele was compared between the groups through the Pearson's chi-square test with Yates's correction. Two-tailed Fisher's test was used when ap

• GR activity prevents GSSG overaccumulation by reducing this

  2022-08-11

  

  GR activity prevents GSSG overaccumulation by reducing this molecule to GSH (Kranner et al., 2006). High GR activity seems to be essential for undisturbed seed germination as GR and other enzymatic antioxidants maintain sunflower (Helianthus annuus L.) seeds vigour (Bailly et al., 2002). Germination

• Flavopiridol hydrochloride synthesis SGCs tightly ensheath t

  2022-08-11

  

  SGCs tightly ensheath the soma of DRG neurons (Costa and Moreira, 2015, Hanani, 2005, Takeda et al., 2009). Intimate associations between SGCs and neurons facilitate bidirectional regulation of SGC function and neuronal excitability. After nerve injury, neuronal hyperexcitability can result in SGC a

• Naringin has been shown to have significant anti

  2022-08-11

  

  Naringin has been shown to have significant anti-inflammation, anti-oxidative stress, glucolipid metabolic regulation, and myocardial protection effects (Gopinath et al., 2011, Gopinath and Sudhandiran, 2012), suggesting that it may mitigate ADC by inhibiting P2X7 receptors. In the present study, na

• Abnormal expression and higher activity of GLO I

  2022-08-11

  

  Abnormal expression and higher activity of GLO I have been detected more in various tumor MG262 than in normal cell samples., , , , , , , Among cancer cell lines, lung carcinoma cells frequently showed higher GLO1 activity. Human NSCLC cell line NCI-H522 cells possess high activity and expression

• br Conclusion Until recently astrocytes were recognized sole

  2022-08-10

  

  Conclusion Until recently, astrocytes were recognized solely for their maintenance role in the regulation of methylphenol homeostasis. Nowadays, this idea has changed, it is clear that these cells play a crucial role in the regulation of neuronal activity and signal transmission. In particular, g

• AZD0156 receptor br Materials and methods br Results and

  2022-08-10

  

  Materials and methods Results and discussion Conclusions Acknowledgements This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684), and also by t

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