• br Conclusion br Conflict of interest

  2022-07-01

  

  Conclusion Conflict of interest statement References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as Introduction Over the past decade, more than a hundred new biopharmaceutical products have been approved and market

• Acarbose and voglibose the classic glucosidase inhibitors we

  2022-07-01

  

  Acarbose and voglibose, the classic α-glucosidase inhibitors, were clinically used to inhibit α-glucosidase activity for the treatment of type 2 diabetes. However, the intake of these drugs may cause some undesirable gastrointestinal side effects and weight gain (Xu et al., 2015). The synthetic drug

• br Conclusion br Ethics statements file br Conflict of inter

  2022-07-01

  

  Conclusion Ethics statements file Conflict of interest Acknowledgements This study was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korean Government (MSIP) (Nos. 2011-0030074 and 2018R1D1A3B07050361) and Sookmyung Women’s University Specialization Pro

• 001 2 In terms of stimulation oxytocin dopamine noradrenalin

  2022-07-01

  

  In terms of stimulation, oxytocin, dopamine, noradrenaline, adrenaline and glucagon have all been reported to increase ghrelin secretion (Mundinger et al., 2006, Iwakura et al., 2011, de la Cour et al., 2007, Gagnon and Anini, 2013). Stimulatory effects on ghrelin secretion have also been observed w

• The snapshots in Fig were taken at

  2022-06-30

  

  The snapshots in Fig. 5 were taken at the end of the first platteau i.e. for 5 Å rmsd or 4 ns time. Thus, we can see that the state of the i-motif affects the mechanism of the G-quadruplex unfolding. At acidic pH the stiff structure of the i-motif does not affect the bottom part (the innermost) of t

• G quadruplex structures can be resolved by helicases Consist

  2022-06-30

  

  G-quadruplex structures can be resolved by helicases. Consistently, many helicases are aberrantly expressed in cancer molarity formula [47]. In this study, we correlated HOXC10 expression with that of all helicases using a microarray dataset derived from 759 breast cancer patients [36] and discover

• The receptor binding assay used in

  2022-06-30

  

  The receptor binding assay used in our previous study demonstrated that propofol competitively binds to FPR1, thus blocking the downstream signal transduction of FPR1 and inhibiting neutrophil immune activities [8]. In this study, we assessed the pharmacological action of fMMYALF in the presence of

• The combination of HIV antigen and antibody testing with

  2022-06-30

  

  The combination of HIV antigen and antibody testing with the fourth generation immunoassays shortens the window lysophosphatidic acid for HIV by detecting HIV antigen, which appears in the blood before seroconversion [3,5,11,12]. Analysis of the seroconversion panels indicated the Elecsys® HIV Duo a

• br Conflict of interest statement br Introduction The Hedgeh

  2022-06-30

  

  Conflict of interest statement Introduction The Hedgehog (Hh) family of secreted protein signals patterns many tissues and structures during embryogenesis (Chiang et al., 1996, Dessaud et al., 2008, Ingham, 1993) and, post-embryonically, governs tissue homeostasis and regeneration by regulatin

• We found that activator drugs decrease NOsGC protein

  2022-06-30

  

  We found that activator drugs decrease NOsGC protein levels in Sf9 cells. This decrease in protein levels is more pronounced for BAY 60–2770 compared to cinaciguat, and more obvious for α1/β1 compared to α2/β1 (see Fig. 2). This led us to hypothesize that the reduction in protein level correlates wi

• The results of our study indicate the general importance of

  2022-06-29

  

  The results of our study indicate the general importance of the gp120 V3 loop nisin receptor patch in the subunit association of primate immunodeficiency virus Env trimers. Our observation that the stem insertion mutants and hydrophobic patch mutants exhibit similar phenotypes with respect to gp120

• There are three classes of

  2022-06-29

  

  There are three classes of receptors for herpes virus gD have been described [18,24]. Among those three, herpes virus entry mediator A (HveA) is also known as HVEM. This receptor is a member of the tumor necrosis factor receptor (TNFR) superfamily [25]. The other class of receptors is HveC which is

• TXA has been shown to be a competitive antagonist

  2022-06-29

  

  TXA has been shown to be a competitive antagonist on the GABAA receptor and potentially also the glycine [7], [12], [15] receptor. Furtmuller et al. showed that TXA right-shifted the GABA CRC by one order of magnitude [7], while in our study TXA similarly right-shifted the GABA EC50 value from 0.33 

• Chlorpromazine HCl In the latent inhibition model a conditio

  2022-06-29

  

  In the latent inhibition model, a conditioned stimulus (CS) is pre-exposed alone without any consequences (i.e., unconditioned stimulus [US]) in the pre-exposure phase. The CS is then associated with a US to form a CS-US association. The strength of the CS-induced response in the pre-exposure group

• Ning et al showed that LPC appeared to increase insulin

  2022-06-29

  

  Ning et al. showed that LPC 18:1 appeared to increase insulin release through both GPR119-dependent and -independent mechanisms (Ning et al., 2008). In our study, we have shown that not only GPR119 but also GPR40 and GPR55 participate in LPC-stimulated insulin secretion (Fig. 4, Fig. 5) and target p

14920 records 416/995 page Previous Next First page 上5页 416417418419420 下5页 Last page